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Quality & Regulatory

The system behind every batch.

Every biosimilar that leaves our Chennai facility is built on a quality system aligned to WHO-GMP, India Schedule M, ICH Q7–Q10 and 21 CFR Part 11 — from raw material intake through final batch release.

WHO-GMP CDSCO / DCGI Schedule M (Revised) ISO 9001:2015 ICH Q7–Q10
Our Quality Philosophy

Built right, not just tested right.

Quality at Regenix is a manufacturing decision, not a post-hoc check. Every batch of insulin, GLP-1 analogue and anticoagulant we ship traces back to a validated process, a qualified facility and a documented person — captured in ALCOA+ records and reviewable on demand by any regulator or partner who asks.

Four Pillars

How the quality system actually works.

Four independent control points — each owned by a separate function and each capable of stopping a batch from shipping if something doesn't add up.

Documentation Control

Every SOP, batch record and analytical method version-controlled, trained, and re-issued on a defined review cadence.

  • 21 CFR Part 11 compliant eSignatures
  • ALCOA+ record integrity
  • Master document index, audit-ready

Process Validation

Equipment qualification (IQ/OQ/PQ), process performance qualification, continued process verification — all linked to a master validation plan.

  • Cleaning validation per APIC
  • Aseptic process simulation (media fills)
  • Annual product quality review (APQR)

Batch Release Testing

Identity, purity, potency, sterility and endotoxin testing performed in-house by qualified analysts on calibrated, IQ/OQ-qualified instruments.

  • USP <71> sterility, USP <85> endotoxin
  • LC-MS identity, RP-HPLC purity
  • Cell-based bioassay for potency

Continuous Improvement

Deviations, OOS investigations and CAPAs feed a structured improvement loop — closed against the root cause, not just the symptom.

  • Root cause analysis (5-Why, fishbone)
  • CAPA effectiveness verification
  • Management review every quarter
Batch Lifecycle

Six checkpoints between raw material and release.

Every batch passes through six controlled stages — each gated, documented and reviewable. No batch leaves the facility without a signed QA release certificate.

01

Raw Material

Identity test, vendor qualification, CoA verification

02

In-process Controls

Critical parameter monitoring, environmental sampling

03

Sterile Fill-Finish

Grade A/B cleanrooms, validated aseptic technique

04

QC Testing

Identity, purity, potency, sterility, endotoxin, particulates

05

QA Review

Batch record review against MFR, deviation closure

06

Release & Dispatch

CoA issue, cold-chain shipper qualification, traceability

Certifications

The credentials behind every dossier.

Every certificate is current, audited and available to qualified partners on request. Site Master File and DMF/CTD summaries shared after a signed NDA.

WHO-GMP

WHO-GMP Certification

Issued by Drugs Control Department, Government of Tamil Nadu

Demonstrates compliance with WHO TRS 986 Annex 2 and TRS 961 Annex 9 — the global baseline for cold-chain biologics manufacturing.

CDSCO

CDSCO / DCGI Licence

Central Drugs Standard Control Organization, Government of India

Manufacturing licence under Drugs and Cosmetics Act, 1940 — separately authorised for each marketed product and dosage form.

Schedule M

Schedule M (Revised)

Indian Pharmacopoeia Commission

Compliant with the revised Schedule M of the Drugs and Cosmetics Rules — India's harmonised GMP standard effective 2024.

ISO 9001

ISO 9001:2015

Accredited certification body

Quality management system certification — process approach, risk-based thinking, continual improvement across the organisation.

ICH Q7–Q10

ICH Quality Guidelines

International Council for Harmonisation

Aligned to Q7 (GMP for APIs), Q8 (Pharmaceutical Development), Q9 (Quality Risk Management) and Q10 (Pharmaceutical Quality System).

21 CFR Part 11

Data Integrity

US FDA / EU GMP Annex 11 aligned

Electronic records and signatures validated to 21 CFR Part 11 and EU GMP Annex 11 — supporting ALCOA+ data integrity throughout the quality system.

Want to audit the quality system?

Partners, regulators and qualified buyers can request a Site Master File summary, audit checklist response, or schedule a facility audit. Reach out to our Quality Assurance team.